Science. 2016 Apr 29;352(6285):539-44. doi: 10.1126/science.aad9378

How colonization by microbiota in early life shapes the immune system.

Gensollen T, Iyer SS, Kasper DL, Blumberg RS.

Abstract:

Microbial colonization of mucosal tissues during infancy plays an instrumental role in the development and education of the host mammalian immune system. These early-life events can have long-standing consequences: facilitating tolerance to environmental exposures or contributing to the development of disease in later life, including inflammatory bowel disease, allergy, and asthma. Recent studies have begun to define a critical period during early development in which disruption of optimal host-commensal interactions can lead to persistent and in some cases irreversible defects in the development and training of specific immune subsets. Here, we discuss the role of early-life education of the immune system during this “window of opportunity,” when microbial colonization has a potentially critical impact on human health and disease.

Copyright © 2016, American Association for the Advancement of Science.

Original Source:

http://www.ncbi.nlm.nih.gov/pubmed/27126036